Yes, the servers I had problems with were all running Trend WFBS. I briefly experimented with their "smart scan" feature, but the constant data churn on the server created huge incrementals...the smart scan feature downloads updates at intervals at least hourly then rebuilds the entire pattern database each time. If you're using Smart scan, turn it off and there will be a huge improvement in your incremental sizes.
Even with the conventional scan updates, the default is to check for updates every hour. There are usually 2 or 3 major updates released per day. The downloaded pattern defs get saved on the server for distribution, then the server makes a copy for its own AV agent. If you are using the version of WFBS-A for Exchange, the server makes another copy of the defs for the Exchange agent. That's a lot of data churn.
At one site I manage which is set up for remote off-site transfers of the backup images, I have had to reduce the update frequency to daily to be able to manage the bandwidth requirement.